Mechanistic targets for BPH and P Ca

Dear All,

It is important for us to understand the intricacies of Molecular and Genetic aspects of development of BPH and P Ca. There are considerable scientific Evidences to prove that both may have a common axis but still BPH cannot be considered as a first step in the development of P Ca. The pathogenesis and progression of BPH is significantly affected by Androgen Signalling, Imbalanced Oxidative Stress and Microbial Infections. In P Ca the predominant factor appears to be with Androgen Signalling but several Genetic alterations have come to the fore. Some of these understandings have been made use for drug developments.

This review gives us more than adequate informations concerning the role played by various targets for the development of BPH and P Ca. (PDF available)

I must complement the authors of this review from Manipal Academy of Higher Education (MAHE) for this timely overview on this complex subject.

With warm Regards,




  • Dr. Roy Chally
    Dr. Roy Chally
    01 Oct 2020 12:16:53 PM

    Nice comprehensive literature review article for basic research workers on BPH and CA Prostate. To me this knowledge now has no practical application. But it is always good to know the progress in basic sciences to understand the technology / medication that will out of this knowledge in future 

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