Epidemiology and Androgen Metabolism among Men with P Ca in Asia
I had placed a write up on Cancer Statistics of Urological Cancers in India. Roy had placed a comment on that by asking a question why the incidence is higher in North East of India. In a review article published in IJU by us on Demography of P Ca in India, we had also observed that the incidence is reported as higher in North East of India. The why is not known as we do not have a detailed epidemiological study.
I am providing informations on Epidemiology of P Ca in Asian Men published in Nature Reviews of Urology, 2021 May Issue.
In 2013 and later in 2017 NCCN Asian Consensus for P Ca have mentioned that there are differences in the Genetic Makeup of P Ca among Asians as against Caucasians. These changes have now been attributed to variations in Single Nucleotide Polymorphisms (SNPs) between Orientals and Caucasians.
We are informed of the various side effects on prolonged administration of any form of ADT on CVS and off late considerable mention are being made regarding Dementia. It has been reported that these events could commence with a year of ADT therapy among Caucasians. But it has been reported and recorded that such events are unusual in Orientals and even on 3 or more years of administration such events are rare. This has been attributed to the genetic aspects of P Ca among Orientals.
I am providing some excerpts from the article published by Yao Zhu*, Dingwei Ye* et al (2021), Nature Reviews Urology, May Issue. (PDF provided)
I am sure we will benefit by the article and I would urge all who have access to nature Reviews of Urology read and understand this study.
With warm regards,