Mechanistic targets for BPH and P Ca
It is important for us to understand the intricacies of Molecular and Genetic aspects of development of BPH and P Ca. There are considerable scientific Evidences to prove that both may have a common axis but still BPH cannot be considered as a first step in the development of P Ca. The pathogenesis and progression of BPH is significantly affected by Androgen Signalling, Imbalanced Oxidative Stress and Microbial Infections. In P Ca the predominant factor appears to be with Androgen Signalling but several Genetic alterations have come to the fore. Some of these understandings have been made use for drug developments.
This review gives us more than adequate informations concerning the role played by various targets for the development of BPH and P Ca.
I must complement the authors of this review from Manipal Academy of Higher Education (MAHE) for this timely overview on this complex subject.
With warm Regards,